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Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts

Metformin is a widely-used treatment for type 2 diabetes and is reported to extend health and lifespan as a caloric restriction (CR) mimetic. Although the benefits of metformin are well documented, the impact of this compound on the function and organization of the genome in normal tissues is unclea...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Gillespie, Zoe E., Wang, Chenxuan, Vadan, Flaviu, Yu, Topaza Y., Ausió, Juan, Kusalik, Anthony, Eskiw, Christopher H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441003/
https://ncbi.nlm.nih.gov/pubmed/30926854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41839-1
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