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Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts

Metformin is a widely-used treatment for type 2 diabetes and is reported to extend health and lifespan as a caloric restriction (CR) mimetic. Although the benefits of metformin are well documented, the impact of this compound on the function and organization of the genome in normal tissues is unclea...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Gillespie, Zoe E., Wang, Chenxuan, Vadan, Flaviu, Yu, Topaza Y., Ausió, Juan, Kusalik, Anthony, Eskiw, Christopher H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441003/
https://ncbi.nlm.nih.gov/pubmed/30926854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41839-1
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