Efficacy of Alectinib in Patients with ALK-Positive NSCLC and Symptomatic or Large CNS Metastases

BACKGROUND: Central nervous system (CNS) metastases represent a significant source of morbidity and mortality for patients with ALK-positive non-small cell lung cancer (NSCLC). Alectinib has demonstrated robust CNS activity in both crizotinib-naïve and crizotinib-resistant settings. However, the CNS...

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Udgivet i:J Thorac Oncol
Main Authors: Lin, Jessica J., Jiang, Ginger Y., Joshipura, Nencyben, Ackil, Jennifer, Digumarthy, Subba R., Rincon, Sandra P., Yeap, Beow Y., Gainor, Justin F., Shaw, Alice T.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440803/
https://ncbi.nlm.nih.gov/pubmed/30529198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2018.12.002
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