In Vitro Susceptibility of Hepatitis C Virus Genotype 1 through 6 Clinical Isolates to the Pangenotypic NS3/4A Inhibitor Voxilaprevir

Voxilaprevir is a direct-acting antiviral agent (DAA) that targets the NS3/4A protease of hepatitis C virus (HCV). High sequence diversity of HCV and inadequate drug exposure during unsuccessful treatment may lead to the accumulation of variants with reduced susceptibility to DAAs, including NS3/4A...

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Bibliographic Details
Published in:J Clin Microbiol
Main Authors: Han, Bin, Parhy, Bandita, Lu, Julia, Zhou, Eric, Hsieh, David, Camus, Gregory, Martin, Ross, Svarovskaia, Evguenia S., Mo, Hongmei, Dvory-Sobol, Hadas
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Virology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440772/
https://ncbi.nlm.nih.gov/pubmed/30728196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01844-18
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