Humanized 3F8 Anti-G(D2) Monoclonal Antibody Dosing With Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Resistant Neuroblastoma: A Phase 1 Clinical Trial

IMPORTANCE: Chimeric and murine anti-G(D2) antibodies are active against neuroblastoma, but the development of neutralizing antibodies can compromise efficacy. To decrease immunogenicity, hu3F8, a humanized anti-G(D2) antibody, was constructed. OBJECTIVE: To find the maximum-tolerated dose of hu3F8...

Full description

Saved in:
Bibliographic Details
Published in:JAMA Oncol
Main Authors: Kushner, Brian H., Cheung, Irene Y., Modak, Shakeel, Basu, Ellen M., Roberts, Stephen S., Cheung, Nai-Kong
Format: Artigo
Language:Inglês
Published: American Medical Association 2018
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440722/
https://ncbi.nlm.nih.gov/pubmed/30326045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2018.4005
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items