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Successful Multifold Dose Escalation of Anti-G(D2) Monoclonal Antibody 3F8 in Patients With Neuroblastoma: A Phase I Study
PURPOSE: Pain can hinder immunotherapy with anti-G(D2) monoclonal antibodies (MoAbs) like 3F8. Heat-modified 3F8 (HM3F8) lacks effector functions and could mask G(D2) or cross-reactive epitopes on nerves, thereby preventing a subsequent dose of unmodified 3F8 from activating pain fibers. We hypothes...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Clinical Oncology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083872/ https://ncbi.nlm.nih.gov/pubmed/21343563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.28.3317 |
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