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Phosphorylation of a serine/proline-rich motif in oxysterol binding protein-related protein 4L (ORP4L) regulates cholesterol and vimentin binding

The family of oxysterol binding protein (OSBP) and OSBP-related proteins (ORPs) mediate sterol and phospholipid transfer and signaling at membrane contact sites (MCS). The activity of OSBP at MCS is regulated by phosphorylation, but whether this applies to ORPs is unknown. Here we report the functio...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pietrangelo, Antonietta, Ridgway, Neale D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440634/
https://ncbi.nlm.nih.gov/pubmed/30925160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0214768
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