Oxysterol-binding Protein (OSBP)-related Protein 4 (ORP4) Is Essential for Cell Proliferation and Survival

Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) comprise a large gene family with sterol/lipid transport and regulatory activities. ORP4 (OSBP2) is a closely related paralogue of OSBP, but its function is unknown. Here we show that ORP4 binds similar sterol and lipid ligands as OSB...

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Detalhes bibliográficos
Main Authors: Charman, Mark, Colbourne, Terry R., Pietrangelo, Antonietta, Kreplak, Laurent, Ridgway, Neale D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140924/
https://ncbi.nlm.nih.gov/pubmed/24742681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.571216
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