Novel Implementation of Genotype‐Guided Proton Pump Inhibitor Medication Therapy in Children: A Pilot, Randomized, Multisite Pragmatic Trial

The efficacy of proton pump inhibitor (PPI) medications is highly dependent on plasma concentrations, which varies considerably due to cytochrome P450 (CYP2C19) genetic variation. We conducted a pragmatic, pilot study of CYP2C19 genotype‐guided pediatric dosing of PPI medications. Children aged 5–17...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Cicali, Emily J., Blake, Kathryn, Gong, Yan, Mougey, Edward B., Al‐Atrash, Hadeel, Chambers, Nancy, Denham, Jolanda, Evans, Jonathan, George, Donald E., Gomez, Roberto, Palomo, Pablo, Taufiq, Salik, Johnson, Julie A., Lima, John J., Franciosi, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440564/
https://ncbi.nlm.nih.gov/pubmed/30341969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12589
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