Novel Implementation of Genotype‐Guided Proton Pump Inhibitor Medication Therapy in Children: A Pilot, Randomized, Multisite Pragmatic Trial

The efficacy of proton pump inhibitor (PPI) medications is highly dependent on plasma concentrations, which varies considerably due to cytochrome P450 (CYP2C19) genetic variation. We conducted a pragmatic, pilot study of CYP2C19 genotype‐guided pediatric dosing of PPI medications. Children aged 5–17...

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Dettagli Bibliografici
Pubblicato in:Clin Transl Sci
Autori principali: Cicali, Emily J., Blake, Kathryn, Gong, Yan, Mougey, Edward B., Al‐Atrash, Hadeel, Chambers, Nancy, Denham, Jolanda, Evans, Jonathan, George, Donald E., Gomez, Roberto, Palomo, Pablo, Taufiq, Salik, Johnson, Julie A., Lima, John J., Franciosi, James P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440564/
https://ncbi.nlm.nih.gov/pubmed/30341969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12589
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