Lamin A mutation impairs interaction with nucleoporin NUP155 and disrupts nucleocytoplasmic transport in atrial fibrillation

Atrial fibrillation (AF) is the most common cardiac arrhythmia. Here, we show the identification and functional characterization of one AF-associated mutation p.Arg399Cys in lamin A/C. Co-immunoprecipitation and GST pull-down assays demonstrate that lamin A/C interacts with NUP155, which is a nucleo...

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Vydáno v:Hum Mutat
Hlavní autoři: Han, Meng, Zhao, Miao, Cheng, Chen, Huang, Yuan, Han, Shengna, Li, Wenjuan, Tu, Xin, Luo, Xuan, Yu, Xiaoling, Liu, Yinan, Chen, Qiuyun, Ren, Xiang, Wang, Qing Kenneth, Ke, Tie
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440547/
https://ncbi.nlm.nih.gov/pubmed/30488537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.23691
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