Lamin A mutation impairs interaction with nucleoporin NUP155 and disrupts nucleocytoplasmic transport in atrial fibrillation

Atrial fibrillation (AF) is the most common cardiac arrhythmia. Here, we show the identification and functional characterization of one AF-associated mutation p.Arg399Cys in lamin A/C. Co-immunoprecipitation and GST pull-down assays demonstrate that lamin A/C interacts with NUP155, which is a nucleo...

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Detalhes bibliográficos
Publicado no:Hum Mutat
Main Authors: Han, Meng, Zhao, Miao, Cheng, Chen, Huang, Yuan, Han, Shengna, Li, Wenjuan, Tu, Xin, Luo, Xuan, Yu, Xiaoling, Liu, Yinan, Chen, Qiuyun, Ren, Xiang, Wang, Qing Kenneth, Ke, Tie
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440547/
https://ncbi.nlm.nih.gov/pubmed/30488537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.23691
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