The HLA-B −21 dimorphism impacts on NK cell education and clinical outcome of immunotherapy in acute myeloid leukemia

Natural killer (NK) cell function is regulated by inhibitory receptors, such as the family of killer immunoglobulin-like receptors (KIRs) and the NKG2A/CD94 heterodimer. These receptors recognize cognate HLA class I molecules on potential target cells, and recent studies imply that an HLA-B dimorphi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Hallner, Alexander, Bernson, Elin, Hussein, Brwa Ali, Ewald Sander, Frida, Brune, Mats, Aurelius, Johan, Martner, Anna, Hellstrand, Kristoffer, Thorén, Fredrik B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Immunobiology and Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440292/
https://ncbi.nlm.nih.gov/pubmed/30647027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-09-874990
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