Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis

IMPORTANCE: Preclinical and human data suggest that hippocampal dysfunction plays a critical role in the onset of psychosis. Neural hyperactivity in the hippocampus is thought to drive an increase in subcortical dopamine function through glutamatergic projections to the striatum. OBJECTIVE: To exami...

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Vydáno v:JAMA Psychiatry
Hlavní autoři: Bossong, Matthijs G., Antoniades, Mathilde, Azis, Matilda, Samson, Carly, Quinn, Beverley, Bonoldi, Ilaria, Modinos, Gemma, Perez, Jesus, Howes, Oliver D., Stone, James M., Allen, Paul, McGuire, Philip
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2018
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440239/
https://ncbi.nlm.nih.gov/pubmed/30427993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamapsychiatry.2018.3252
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