Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders

IMPORTANCE: Neuronal and axonal destruction are hallmarks of neurodegenerative diseases, but it is difficult to estimate the extent and progress of the damage in the disease process. OBJECTIVE: To investigate cerebrospinal fluid (CSF) levels of neurofilament light (NFL) protein, a marker of neuroaxo...

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Détails bibliographiques
Publié dans:JAMA Neurol
Auteurs principaux: Olsson, Bob, Portelius, Erik, Cullen, Nicholas C., Sandelius, Åsa, Zetterberg, Henrik, Andreasson, Ulf, Höglund, Kina, Irwin, David J., Grossman, Murray, Weintraub, Daniel, Chen-Plotkin, Alice, Wolk, David, McCluskey, Leo, Elman, Lauren, Shaw, Leslie M., Toledo, Jon B., McBride, Jennifer, Hernandez-Con, Pilar, Lee, Virginia M-Y., Trojanowski, John Q., Blennow, Kaj
Format: Artigo
Langue:Inglês
Publié: American Medical Association 2018
Sujets:
Original Investigation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440232/
https://ncbi.nlm.nih.gov/pubmed/30508027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2018.3746
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