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The secreted APP ectodomain sAPPα, but not sAPPβ, protects neurons against Aβ oligomer-induced dendritic spine loss and increased tau phosphorylation

AIM: The amyloid precursor protein (APP) is endoproteolytically processed to generate either the neurotoxic beta-amyloid peptide (Aβ) or the secreted ectodomain APP alpha (sAPPα). While neurotrophic properties of sAPPα were suggested in several studies, it is still unclear if and how sAPPα counterac...

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Publicat a:Mol Brain
Autors principals: Tackenberg, Christian, Nitsch, Roger M.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440141/
https://ncbi.nlm.nih.gov/pubmed/30922360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-019-0447-2
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