Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease

IMPORTANCE: Use of thiopurines may be limited by myelosuppression. TPMT pharmacogenetic testing identifies only 25% of at-risk patients of European ancestry. Among patients of East Asian ancestry, NUDT15 variants are associated with thiopurine-induced myelosuppression (TIM). OBJECTIVE: To identify g...

Full description

Saved in:
Bibliographic Details
Published in:JAMA
Main Authors: Walker, Gareth J., Harrison, James W., Heap, Graham A., Voskuil, Michiel D., Andersen, Vibeke, Anderson, Carl A., Ananthakrishnan, Ashwin N., Barrett, Jeffrey C., Beaugerie, Laurent, Bewshea, Claire M., Cole, Andy T., Cummings, Fraser R., Daly, Mark J., Ellul, Pierre, Fedorak, Richard N., Festen, Eleonora A. M., Florin, Timothy H., Gaya, Daniel R., Halfvarson, Jonas, Hart, Ailsa L., Heerasing, Neel M., Hendy, Peter, Irving, Peter M., Jones, Samuel E., Koskela, Jukka, Lindsay, James O., Mansfield, John C., McGovern, Dermot, Parkes, Miles, Pollok, Richard C. G., Ramakrishnan, Subramaniam, Rampton, David S., Rivas, Manuel A., Russell, Richard K., Schultz, Michael, Sebastian, Shaji, Seksik, Philippe, Singh, Abhey, So, Kenji, Sokol, Harry, Subramaniam, Kavitha, Todd, Anthony, Annese, Vito, Weersma, Rinse K., Xavier, Ramnik, Ward, Rebecca, Weedon, Michael N., Goodhand, James R., Kennedy, Nicholas A., Ahmad, Tariq
Format: Artigo
Language:Inglês
Published: American Medical Association 2019
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6439872/
https://ncbi.nlm.nih.gov/pubmed/30806694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2019.0709
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items