Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons

G protein-coupled receptors are key signaling molecules and major targets for pharmaceuticals. The concept of ligand-dependent biased signaling raises the possibility of developing drugs with improved efficacy and safety profiles, yet translating this concept to native tissues remains a major challe...

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Pubblicato in:iScience
Autori principali: Ehrlich, Aliza T., Semache, Meriem, Gross, Florence, Da Fonte, Dillon F., Runtz, Leonie, Colley, Christine, Mezni, Amina, Le Gouill, Christian, Lukasheva, Viktoriya, Hogue, Mireille, Darcq, Emmanuel, Bouvier, Michel, Kieffer, Brigitte L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6439305/
https://ncbi.nlm.nih.gov/pubmed/30925410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.03.011
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