Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons

G protein-coupled receptors are key signaling molecules and major targets for pharmaceuticals. The concept of ligand-dependent biased signaling raises the possibility of developing drugs with improved efficacy and safety profiles, yet translating this concept to native tissues remains a major challe...

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Publicado en:iScience
Main Authors: Ehrlich, Aliza T., Semache, Meriem, Gross, Florence, Da Fonte, Dillon F., Runtz, Leonie, Colley, Christine, Mezni, Amina, Le Gouill, Christian, Lukasheva, Viktoriya, Hogue, Mireille, Darcq, Emmanuel, Bouvier, Michel, Kieffer, Brigitte L.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6439305/
https://ncbi.nlm.nih.gov/pubmed/30925410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.03.011
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