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Biphasic effect of abstinence duration following cocaine self-administration on spine morphology and plasticity-related proteins in prelimbic cortical neurons projecting to the nucleus accumbens core

Cocaine self-administration (SA) in rats dysregulates glutamatergic signaling in the prelimbic (PrL) cortex and glutamate release in the nucleus accumbens (NA) core, promoting cocaine seeking. PrL adaptations that affect relapse to drug seeking emerge during the first week of abstinence; switching f...

詳細記述

保存先:
書誌詳細
出版年:Brain Struct Funct
主要な著者: BM, Siemsen, G, Giannotti, JA, McFaddin, MD, Scofield, JF, McGinty
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438710/
https://ncbi.nlm.nih.gov/pubmed/30498893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00429-018-1805-z
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