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Screening the ToxCast Phase II Libraries for Alterations in Network Function using Cortical Neurons Grown on Multi-well Microelectrode Array (mwMEA) Plates

Methods are needed for rapid screening of environmental compounds for neurotoxicity, particularly ones that assess function. To demonstrate the utility of microelectrode array (MEA)-based approaches as a rapid neurotoxicity screening tool, 1055 chemicals from EPA’s Phase II ToxCast library were eval...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Strickland, Jenna D., Martin, Matthew T., Richard, Ann M., Houck, Keith A., Shafer, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438628/
https://ncbi.nlm.nih.gov/pubmed/28766123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2035-5
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