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Label-free target identification reveals oxidative DNA damage as the mechanism of a selective cytotoxic agent

Phenotypic screening can not only identify promising first-in-class drug candidates, but can also reveal potential therapeutic targets or neomorphic functions of known proteins. In this study, we identified target proteins of SB2001, a cytotoxic agent that acts specifically against HeLa human cervic...

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Vydáno v:Chem Sci
Hlavní autoři: Park, Hankum, Park, Seung Bum
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438152/
https://ncbi.nlm.nih.gov/pubmed/30996934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05465g
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