Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N‐terminal Inhibitors Without Induction of Heat Shock Response

Heat shock protein 90 (Hsp90) is a potential oncogenic target. However, Hsp90 inhibitors in clinical trial induce heat shock response, resulting in drug resistance and inefficiency. In this study, we designed and synthesized a series of novel triazine derivatives (A1‐26, B1‐13, C1‐23) as Hsp90 inhib...

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Veröffentlicht in:ChemistryOpen
Hauptverfasser: Liu, Peng, Chen, Xiangling, Zhu, Jianming, Li, Bo, Chen, Zhaoqiang, Wang, Guimin, Sun, Haiguo, Xu, Zhijian, Zhao, Zhixin, Zhou, Chen, Xie, Chengying, Lou, Liguang, Zhu, Weiliang
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437812/
https://ncbi.nlm.nih.gov/pubmed/30976475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201900055
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