Efficient bioactive oligonucleotide‐protein conjugation for cell‐targeted cancer therapy

Oligonucleotide‐protein conjugates have important applications in biomedicine. Simple and efficient methods are described for the preparation of these conjugates. Specifically, we describe a new method in which a bifunctional linker is attached to thiol‐oligonucleotide to generate a reactive interme...

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Bibliografiske detaljer
Udgivet i:ChemistryOpen
Main Authors: Aviñó, Anna, Unzueta, Ugutz, Virtudes Céspedes, María, Casanova, Isolda, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon, Eritja, Ramon
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437810/
https://ncbi.nlm.nih.gov/pubmed/30976478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201900038
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