Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of advanced chronic liver disease. The progression of NAFLD, including nonalcoholic steatohepatitis (NASH), has a strong genetic component, and the most robust contributor is the patatin-like phospholipase domain-contain...

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Veröffentlicht in:Mol Metab
Hauptverfasser: Lindén, Daniel, Ahnmark, Andrea, Pingitore, Piero, Ciociola, Ester, Ahlstedt, Ingela, Andréasson, Anne-Christine, Sasidharan, Kavitha, Madeyski-Bengtson, Katja, Zurek, Magdalena, Mancina, Rosellina M., Lindblom, Anna, Bjursell, Mikael, Böttcher, Gerhard, Ståhlman, Marcus, Bohlooly-Y, Mohammad, Haynes, William G., Carlsson, Björn, Graham, Mark, Lee, Richard, Murray, Sue, Valenti, Luca, Bhanot, Sanjay, Åkerblad, Peter, Romeo, Stefano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437635/
https://ncbi.nlm.nih.gov/pubmed/30772256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.01.013
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