Efficacy of Intranasal Administration of the Recombinant Endolysin SAL200 in a Lethal Murine Staphylococcus aureus Pneumonia Model

SAL200 is derived from a phage endolysin and is a novel candidate drug for the treatment of Staphylococcus aureus infection. We investigated the efficacy of the recombinant endolysin SAL200 in a lethal murine pneumonia model. Lethal pneumonia was established by intranasally administering a methicill...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Bae, Ji Yun, Jun, Kang Il, Kang, Chang Kyung, Song, Kyoung-Ho, Choe, Pyoeng Gyun, Bang, Ji-Hwan, Kim, Eu Suk, Park, Sang Won, Kim, Hong Bin, Kim, Nam-Joong, Park, Wan Beom, Oh, Myoung-don
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437543/
https://ncbi.nlm.nih.gov/pubmed/30670417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02009-18
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