Activity of a Long-Acting Injectable Bedaquiline Formulation in a Paucibacillary Mouse Model of Latent Tuberculosis Infection

The potent antituberculosis activity and long half-life of bedaquiline make it an attractive candidate for use in long-acting/extended-release formulations for the treatment of latent tuberculosis infection (LTBI). Our objective was to evaluate a long-acting injectable (LAI) bedaquiline formulation...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Kaushik, Amit, Ammerman, Nicole C., Tyagi, Sandeep, Saini, Vikram, Vervoort, Iwan, Lachau-Durand, Sophie, Nuermberger, Eric, Andries, Koen
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437534/
https://ncbi.nlm.nih.gov/pubmed/30745396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00007-19
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