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Resurrecting Old β-Lactams: Potent Inhibitory Activity of Temocillin against Multidrug-Resistant Burkholderia Species Isolates from the United States

Burkholderia spp. are opportunistic human pathogens that infect persons with cystic fibrosis and the immunocompromised. Burkholderia spp. express class A and C β-lactamases, which are transcriptionally regulated by PenR(A) through linkage to cell wall metabolism and β-lactam exposure. The potency of...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Zeiser, Elise T., Becka, Scott A., Barnes, Melissa D., Taracila, Magdalena A., LiPuma, John J., Papp-Wallace, Krisztina M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437531/
https://ncbi.nlm.nih.gov/pubmed/30718248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02315-18
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