Pharmacological, Toxicological, and Dose Range Assessment of OG716, a Novel Lantibiotic for the Treatment of Clostridium difficile-Associated Infection

Lantibiotics present an attractive scaffold for the development of novel antibiotics. We report here a novel lantibiotic for the treatment of Clostridium difficile infection. The lead compounds were selected from a library of over 700 single- and multiple-substitution variants of the lantibiotic mut...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Pulse, Mark E., Weiss, William J., Kers, Johan A., DeFusco, Anthony W., Park, Jae H., Handfield, Martin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437525/
https://ncbi.nlm.nih.gov/pubmed/30670434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01904-18
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