Various Evolutionary Trajectories Lead to Loss of the Tobramycin-Potentiating Activity of the Quorum-Sensing Inhibitor Baicalin Hydrate in Burkholderia cenocepacia Biofilms

Combining antibiotics with potentiators that increase their activity is a promising strategy to tackle infections caused by antibiotic-resistant bacteria. As potentiators do not interfere with essential processes, it has been hypothesized that they are less likely to induce resistance. However, evid...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Sass, Andrea, Slachmuylders, Lisa, Van Acker, Heleen, Vandenbussche, Ian, Ostyn, Lisa, Bové, Mona, Crabbé, Aurélie, Chiarelli, Laurent R., Buroni, Silvia, Van Nieuwerburgh, Filip, Abatih, Emmanuel, Coenye, Tom
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437513/
https://ncbi.nlm.nih.gov/pubmed/30670425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02092-18
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