APX001 Pharmacokinetic/Pharmacodynamic Target Determination against Aspergillus fumigatus in an In Vivo Model of Invasive Pulmonary Aspergillosis

APX001, the prodrug of APX001A, is a first-in-class antifungal agent that has a potent activity against Aspergillus fumigatus. The goal of current study was to determine the pharmacodynamic (PD) index and target of APX001 in an immunocompromised murine model of invasive pulmonary aspergillosis again...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Zhao, Miao, Lepak, Alexander J., Marchillo, Karen, Vanhecker, Jamie, Sanchez, Hiram, Ambrose, Paul G., Andes, David R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437477/
https://ncbi.nlm.nih.gov/pubmed/30670426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02372-18
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