Human Bone Marrow Endothelial Progenitor Cell Transplantation into Symptomatic ALS Mice Delays Disease Progression and Increases Motor Neuron Survival by Repairing Blood-Spinal Cord Barrier

Convincing evidence demonstrated impairment of the blood-spinal cord barrier (BSCB) in Amyotrophic Lateral Sclerosis (ALS), mainly by endothelial cell (EC) alterations. Replacing damaged ECs by cell transplantation is a potential barrier repair strategy. Recently, we showed that intravenous (iv) adm...

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Pubblicato in:Sci Rep
Autori principali: Garbuzova-Davis, Svitlana, Kurien, Crupa, Haller, Edward, Eve, David J., Navarro, Stephanie, Steiner, George, Mahendrasah, Ajay, Hailu, Surafuale, Khatib, Mohammed, Boccio, Kayla J., Borlongan, Cesario V., Van Loveren, Harry R., Appel, Stanley H., Sanberg, Paul R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437219/
https://ncbi.nlm.nih.gov/pubmed/30918315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41747-4
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