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Cooperativity and allostery in aquaporin 0 regulation by Ca(2+)

Aquaporin 0 (AQP0) is essential for eye lens homeostasis as is regulation of its water permeability by Ca(2+), which occurs through interactions with Calmodulin (CaM), but the underlying molecular mechanisms are not well understood. Here, we use molecular dynamics (MD) simulations on the microsecond...

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發表在:Biochim Biophys Acta Biomembr
Main Authors: Freites, J. Alfredo, Németh-Cahalan, Karin L., Hall, James E., Tobias, Douglas J.
格式: Artigo
語言:Inglês
出版: 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437002/
https://ncbi.nlm.nih.gov/pubmed/30802427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2019.02.007
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