Trio Haploinsufficiency Causes Neurodevelopmental Disease–Associated Deficits

Heterozygous coding mutations in TRIO are associated with neurodevelopmental disorders, including autism, schizophrenia, bipolar disorder, and epilepsy, and impair TRIO’s biochemical activities. To model mutant alleles, we ablated one or both Trio alleles from excitatory neurons in the cortex and hi...

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Pubblicato in:Cell Rep
Autori principali: Katrancha, Sara Marie, Shaw, Juliana E., Zhao, Amy Y., Myers, Samuel A., Cocco, Alexandra R., Jeng, Amanda T., Zhu, Minsheng, Pittenger, Christopher, Greer, Charles A., Carr, Steven A., Xiao, Xiao, Koleske, Anthony J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436967/
https://ncbi.nlm.nih.gov/pubmed/30840899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.022
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