Trio Haploinsufficiency Causes Neurodevelopmental Disease–Associated Deficits

Heterozygous coding mutations in TRIO are associated with neurodevelopmental disorders, including autism, schizophrenia, bipolar disorder, and epilepsy, and impair TRIO’s biochemical activities. To model mutant alleles, we ablated one or both Trio alleles from excitatory neurons in the cortex and hi...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Katrancha, Sara Marie, Shaw, Juliana E., Zhao, Amy Y., Myers, Samuel A., Cocco, Alexandra R., Jeng, Amanda T., Zhu, Minsheng, Pittenger, Christopher, Greer, Charles A., Carr, Steven A., Xiao, Xiao, Koleske, Anthony J.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436967/
https://ncbi.nlm.nih.gov/pubmed/30840899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.022
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