Trio Haploinsufficiency Causes Neurodevelopmental Disease–Associated Deficits

Heterozygous coding mutations in TRIO are associated with neurodevelopmental disorders, including autism, schizophrenia, bipolar disorder, and epilepsy, and impair TRIO’s biochemical activities. To model mutant alleles, we ablated one or both Trio alleles from excitatory neurons in the cortex and hi...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Katrancha, Sara Marie, Shaw, Juliana E., Zhao, Amy Y., Myers, Samuel A., Cocco, Alexandra R., Jeng, Amanda T., Zhu, Minsheng, Pittenger, Christopher, Greer, Charles A., Carr, Steven A., Xiao, Xiao, Koleske, Anthony J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436967/
https://ncbi.nlm.nih.gov/pubmed/30840899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.022
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