Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke

Ischemic stroke is a predominant cause of disability worldwide, with thrombolytic or mechanical removal of the occlusion being the only therapeutic option. Reperfusion bears the risk of an acute deleterious calcium-dependent breakdown of the blood-brain barrier. Its mechanism, however, is unknown. H...

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Pubblicato in:J Clin Invest
Autori principali: Casas, Ana I., Kleikers, Pamela W.M., Geuss, Eva, Langhauser, Friederike, Adler, Thure, Busch, Dirk H., Gailus-Durner, Valerie, de Angelis, Martin Hrabê, Egea, Javier, Lopez, Manuela G., Kleinschnitz, Christoph, Schmidt, Harald H.H.W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
Soggetti:
Concise Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436900/
https://ncbi.nlm.nih.gov/pubmed/30882367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124283
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