Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity

BACKGROUND. The human bone marrow (BM) niche contains a population of mesenchymal stromal cells (MSCs) that provide physical support and regulate hematopoietic stem cell (HSC) homeostasis. β-Thalassemia (BT) is a hereditary disorder characterized by altered hemoglobin beta-chain synthesis amenable t...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Crippa, Stefania, Rossella, Valeria, Aprile, Annamaria, Silvestri, Laura, Rivis, Silvia, Scaramuzza, Samantha, Pirroni, Stefania, Avanzini, Maria Antonietta, Basso-Ricci, Luca, Hernandez, Raisa Jofra, Zecca, Marco, Marktel, Sarah, Ciceri, Fabio, Aiuti, Alessandro, Ferrari, Giuliana, Bernardo, Maria Ester
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
Subjects:
Clinical Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436882/
https://ncbi.nlm.nih.gov/pubmed/30830876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123191
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