Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model

Mitofusin-2 (MFN2) is a mitochondrial outer-membrane protein that plays a pivotal role in mitochondrial dynamics in most tissues, yet mutations in MFN2, which cause Charcot-Marie-Tooth disease type 2A (CMT2A), primarily affect the nervous system. We generated a transgenic mouse model of CMT2A that d...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zhou, Yueqin, Carmona, Sharon, Muhammad, A.K.M.G., Bell, Shaughn, Landeros, Jesse, Vazquez, Michael, Ho, Ritchie, Franco, Antonietta, Lu, Bin, Dorn, Gerald W., Wang, Shaomei, Lutz, Cathleen M., Baloh, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436852/
https://ncbi.nlm.nih.gov/pubmed/30882371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124194
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados