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Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model
Mitofusin-2 (MFN2) is a mitochondrial outer-membrane protein that plays a pivotal role in mitochondrial dynamics in most tissues, yet mutations in MFN2, which cause Charcot-Marie-Tooth disease type 2A (CMT2A), primarily affect the nervous system. We generated a transgenic mouse model of CMT2A that d...
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| Pubblicato in: | J Clin Invest |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6436852/ https://ncbi.nlm.nih.gov/pubmed/30882371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124194 |
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