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Failure to reabsorb the primary cilium induces cellular senescence
Aurora kinase A (AURKA) is necessary for proper primary cilium disassembly before mitosis. We found that depletion of caveolin-1 expression promotes primary cilia formation through the proteasomal-dependent degradation of aurora kinase A and induces premature senescence in human fibroblasts. Down-re...
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| Gepubliceerd in: | FASEB J |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Federation of American Societies for Experimental Biology
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6436649/ https://ncbi.nlm.nih.gov/pubmed/30596512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801382R |
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