Loss of Wnt Secretion by Macrophages Promotes Hepatobiliary Injury after Administration of 3,5-Diethoxycarbonyl-1, 4-Dihydrocollidine Diet

Exposure of mice to a diet containing 3,5-diethoxycarbonyl-1, 4-dihydrocollidine (DDC) induces porphyrin accumulation, cholestasis, immune response, and hepatobiliary damage mimicking hepatic porphyria and sclerosing cholangitis. Although β-catenin signaling promotes hepatocyte proliferation, and ma...

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Détails bibliographiques
Publié dans:Am J Pathol
Auteurs principaux: Jiang, An, Okabe, Hirohisa, Popovic, Branimir, Preziosi, Morgan E., Pradhan-Sundd, Tirthadipa, Poddar, Minakshi, Singh, Sucha, Bell, Aaron, England, Steven G., Nagarajan, Shanmugam, Monga, Satdarshan P.
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436111/
https://ncbi.nlm.nih.gov/pubmed/30610845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.11.010
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