Inhibition of IL-17 ameliorates systemic lupus erythematosus in Roquin(san/san) mice through regulating the balance of TFH cells, GC B cells, Treg and Breg

Systemic lupus erythematosus (SLE) is mediated by a chronic and dysregulated inflammatory response. Interleukin (IL)-17, a proinflammatory cytokine, and T helper (Th)17 cells are associated with chronic autoimmune diseases. We hypothesized that inhibition of IL-17 would decrease the numbers of T cel...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lee, Seon-yeong, Lee, Seung Hoon, Seo, Hyeon-Beom, Ryu, Jun-Geol, Jung, KyungAh, Choi, Jeong Won, Jhun, JooYeon, Park, Jin-Sil, Kwon, Ji Ye, Kwok, Seung-Ki, Youn, Jeehee, Park, Sung-Hwan, Cho, Mi-La
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435653/
https://ncbi.nlm.nih.gov/pubmed/30914691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41534-1
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