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DNA phosphorothioate modification—a new multi-functional epigenetic system in bacteria

Synthetic phosphorothioate (PT) internucleotide linkages, in which a nonbridging oxygen is replaced by a sulphur atom, share similar physical and chemical properties with phosphodiesters but confer enhanced nuclease tolerance on DNA/RNA, making PTs a valuable biochemical and pharmacological tool. In...

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Podrobná bibliografie
Vydáno v:FEMS Microbiol Rev
Hlavní autoři: Wang, Lianrong, Jiang, Susu, Deng, Zixin, Dedon, Peter C, Chen, Shi
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435447/
https://ncbi.nlm.nih.gov/pubmed/30289455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femsre/fuy036
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