Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming

Forced transcription factor expression can transdifferentiate somatic cells into other specialised cell types or reprogram them into induced pluripotent stem cells (iPSCs) with variable efficiency. To better understand the heterogeneity of these processes, we used single-cell RNA sequencing to follo...

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Gepubliceerd in:eLife
Hoofdauteurs: Francesconi, Mirko, Di Stefano, Bruno, Berenguer, Clara, de Andrés-Aguayo, Luisa, Plana-Carmona, Marcos, Mendez-Lago, Maria, Guillaumet-Adkins, Amy, Rodriguez-Esteban, Gustavo, Gut, Marta, Gut, Ivo G, Heyn, Holger, Lehner, Ben, Graf, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2019
Onderwerpen:
Computational and Systems Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435319/
https://ncbi.nlm.nih.gov/pubmed/30860479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41627
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