MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma

BACKGROUND: Mitochondrial Ca(2+) plays a critical role in tumorigenesis, including cell proliferation and metastasis. Mitochondrial calcium uniporter regulator 1 (MCUR1) has been shown to be frequently upregulated in HCC and promote cancer cell survival. However, whether MCUR1 is involved in the met...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Jin, Mingpeng, Wang, Jiaojiao, Ji, Xiaoying, Cao, Haiyan, Zhu, Jianjun, Chen, Yibing, Yang, Jin, Zhao, Zheng, Ren, Tingting, Xing, Jinliang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434841/
https://ncbi.nlm.nih.gov/pubmed/30909929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1135-x
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