TNFα induces Ca(2+) influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells

BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated dose, which need urgently to be solved. METHO...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Zhu, Jianjun, Jin, Mingpeng, Wang, Jiaojiao, Zhang, Hui, Wu, Yousheng, Li, Deyang, Ji, Xiaoying, Yang, Hushan, Yin, Chun, Ren, Tingting, Xing, Jinliang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838867/
https://ncbi.nlm.nih.gov/pubmed/29506556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0714-6
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