TNFα induces Ca(2+) influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells

BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated dose, which need urgently to be solved. METHO...

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Podrobná bibliografie
Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Zhu, Jianjun, Jin, Mingpeng, Wang, Jiaojiao, Zhang, Hui, Wu, Yousheng, Li, Deyang, Ji, Xiaoying, Yang, Hushan, Yin, Chun, Ren, Tingting, Xing, Jinliang
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838867/
https://ncbi.nlm.nih.gov/pubmed/29506556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0714-6
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