High prevalence of Pfdhfr–Pfdhps quadruple mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea

BACKGROUND: Sulfadoxine–pyrimethamine (SP) is recommended for intermittent preventive treatment of malaria in Africa. However, increasing SP resistance (SPR) affects the therapeutic efficacy of the SP. As molecular markers, Pfdhfr (dihydrofolate reductase) and Pfdhps (dihydropteroate synthase) genes...

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Detalles Bibliográficos
Publicado en:Malar J
Main Authors: Jiang, Tingting, Chen, Jiangtao, Fu, Hongxia, Wu, Kai, Yao, Yi, Eyi, Juan Urbano Monsuy, Matesa, Rocio Apicante, Obono, Maximo Miko Ondo, Du, Weixing, Tan, Huabing, Lin, Min, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434785/
https://ncbi.nlm.nih.gov/pubmed/30914041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-019-2734-x
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