High prevalence of Pfdhfr–Pfdhps quadruple mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea

BACKGROUND: Sulfadoxine–pyrimethamine (SP) is recommended for intermittent preventive treatment of malaria in Africa. However, increasing SP resistance (SPR) affects the therapeutic efficacy of the SP. As molecular markers, Pfdhfr (dihydrofolate reductase) and Pfdhps (dihydropteroate synthase) genes...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Jiang, Tingting, Chen, Jiangtao, Fu, Hongxia, Wu, Kai, Yao, Yi, Eyi, Juan Urbano Monsuy, Matesa, Rocio Apicante, Obono, Maximo Miko Ondo, Du, Weixing, Tan, Huabing, Lin, Min, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434785/
https://ncbi.nlm.nih.gov/pubmed/30914041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-019-2734-x
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