Magnolol induces cell death through PI3K/Akt‐mediated epigenetic modifications boosting treatment of BRAF‐ and NRAS‐mutant melanoma

Most BRAF‐mutant melanoma patients experience a fulminate relapse after several months of treatment with BRAF/MEK inhibitors. To improve therapeutic efficacy, natural plant‐derived compounds might be considered as potent additives. Here, we show that magnolol, a constituent of Magnolia officinalis,...

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Bibliografiska uppgifter
I publikationen:Cancer Med
Huvudupphovsmän: Emran, Abdullah Al, Chinna Chowdary, Brinda Reddy, Ahmed, Farzana, Hammerlindl, Heinz, Huefner, Antje, Haass, Nikolas K., Schuehly, Wolfgang, Schaider, Helmut
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Cancer Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434221/
https://ncbi.nlm.nih.gov/pubmed/30793515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1978
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