Shiga Toxin Type 1a (Stx1a) Reduces the Toxicity of the More Potent Stx2a In Vivo and In Vitro

Shiga toxin (Stx)-producing Escherichia coli (STEC) causes foodborne outbreaks of bloody diarrhea. There are two major types of immunologically distinct Stxs: Stx1a and Stx2a. Stx1a is more cytotoxic to Vero cells than Stx2a, but Stx2a has a lower 50% lethal dose (LD(50)) in mice. Epidemiological da...

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Publicat a:Infect Immun
Autors principals: Petro, Courtney D., Trojnar, Eszter, Sinclair, James, Liu, Zhi-Mei, Smith, Mark, O’Brien, Alison D., Melton-Celsa, Angela
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Molecular Pathogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434123/
https://ncbi.nlm.nih.gov/pubmed/30670557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00787-18
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